Nonselective cation channel as a Ca influx pathway in pepsinogen-secreting cells of bullfrog esophagus
نویسندگان
چکیده
SEIICHIRO KIMURA,1 HIROSHI MIENO,2 KENJI TAMAKI,3 MASAKI INOUE,4 AND KAZUAKI CHAYAMA5 1Saiseikai Kure Hospital, Kure City, Hiroshima 737-0821; 2Hiroshima General Hospital of the West Railroad Company, Hiroshima City, Hiroshima 732-0057; 3Chugoku Rosai Hospital, Kure City, Hiroshima 737-0193; and 4Department of Geriatric Medicine and First 5Department of Internal Medicine, Institute of Health Sciences, Hiroshima University School of Medicine, Hiroshima 734-8551, Japan
منابع مشابه
Nonselective cation channel as a Ca(2+) influx pathway in pepsinogen-secreting cells of bullfrog esophagus.
In pepsinogen-secreting cells of bullfrog (Rana catesbeiana), recent evidence suggests that Ca(2+) release from internal stores followed by Ca(2+) influx across the plasma membrane elicits pepsinogen secretion. Such a Ca(2+) influx could be carried by a background current, potentiated by bombesin, that was found in these cells using the whole cell patch-clamp technique. The permeability ratio o...
متن کاملCorticotropin-releasing Hormone Activates a Nonselective Cation
The mechanisms of corticotropin-releasing hormone (CRH)– induced excitation of ACTH-secreting adenoma cells were investigated using the perforated whole-cell clamp technique and intracellular Ca 2 1 concentration ([Ca 2 1 ] i ) measurement. CRH depolarized ACTH-secreting adenoma cells by activating a nonselective cation current that showed slight inward rectification. This channel did not seem ...
متن کاملTRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells.
Nonselective cation channels may play a role in insulin secretion by regulating pancreatic beta-cell plasma membrane potential, Ca(2+) homeostasis, and thereby glucose signaling. Transient receptor potential channel (TRPC)-related genes encode nonselective cation channels, some of which are similar to those described for beta-cells. Some TRPC-like channels are activated via G-protein--coupled m...
متن کاملA weakly voltage-dependent, nonselective cation channel mediates toxic sodium influx in wheat.
To determine the transporters responsible for toxic Na(+) influx in wheat (Triticum aestivum), root plasma membrane preparations were screened using the planar lipid bilayer technique as an assay for Na(+)-permeable ion channel activity. The predominant channel in the bilayer was a 44-pS channel that we called the nonselective cation (NSC) channel, which was nonselective for monovalent cations ...
متن کاملRole of nonselective cation channels in spontaneous and protein kinase A-stimulated calcium signaling in pituitary cells.
Several receptors linked to the adenylyl cyclase signaling pathway stimulate electrical activity and calcium influx in endocrine pituitary cells, and a role for an unidentified sodium-conducting channel in this process has been proposed. Here we show that forskolin dose-dependently increases cAMP production and facilitates calcium influx in about 30% of rat and mouse pituitary cells at its maxi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2001